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Synthesis of Isocoumarin Derivatives by Copper-Catalyzed Addition of o-Halobenzoic Acids to Active Internal Alkynes

Xun-Xiang Guo*

*Shanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China, Email:

X.-X. Guo, J. Org. Chem., 2013, 78, 1660-1664.

DOI: 10.1021/jo302499k


A simple addition of o-halobenzoic acids to active internal alkynes proceeds efficiently in the presence of CuCl2 as a catalyst to give the corresponding isocoumarin derivatives.

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ID: J42-Y2013-0440