Effective Palladium-Catalyzed Hydroxycarbonylation of Aryl Halides with Substoichiometric Carbon Monoxide
Signe Korsager, Rolf H. Taaning and Troels Skrydstrup*
*Department of Chemistry and the Interdisciplinary
Nanoscience Center, Aarhus University, Gustavs Wieds Vej 14, 8000 Aarhus,
Denmark, Email: ts
chem.au.dk
S. Korsager, R. H. Taaning, T. Skrydstrup, J. Am. Chem. Soc., 2013, 135, 2891-2894.
DOI: 10.1021/ja3114032
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Abstract
Only 1-5 mol % of CO are needed to enable a Pd-catalyzed hydroxycarbonylation of aryl iodides, bromides, and chlorides in the presence of potassium formate as the only stoichiometric, mildly basic nucleophile and a reservoir of CO. The substoichiometric CO is generated in situ from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling the toxic gas.
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Key Words
ID: J48-Y2013-0450
