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XtalFluor-E, an Efficient Coupling Reagent for Amidation of Carboxylic Acids

Aurélie Orliac, Domingo Gomez Pardo*, Agnès Bombrun and Janine Cossy*

*Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France, Email:,

A. Orliac, D. G. Pardo, A. Bombrun, J. Cossy, Org. Lett., 2013, 15, 902-905.

DOI: 10.1021/ol400045d


Amides were produced from carboxylic acids and amines in the presence of XtalFluor-E as an activator. Optically active amines and/or carboxylic acids were not epimerized/racemized during the process and even poorly reactive carboxylic acids can be transformed to amides.

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ID: J54-Y2013-0460