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Cu(OAc)2-Catalyzed Thiolation of Acyl C-H Bonds with Thiols Using TBHP as an Oxidant

Yan-qin Yuan*, Sheng-rong Guo, Jian-nan Xiang*

*Department of Chemistry, Lishui University, 323000 Lishui and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China, Email:,

Y.-q. Yuan, S.-r. Guo, J.-n. Xiang, Synlett, 2013, 24, 443-448.

DOI: 10.1055/s-0032-1318188


Cu(OAc)2-promoted TBHP oxidative coupling reaction of formamides with thiophenols gives S-aryl dialkyl thiocarbamates in high yield under solvent-free conditions through direct C-H bond activation of formamides.

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Key Words

TBHP, Cu(OAc)2, thiolation, thiols, formamides

ID: J60-Y2013-0490