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Cu(OAc)2-Catalyzed Thiolation of Acyl C-H Bonds with Thiols Using TBHP as an Oxidant

Yan-qin Yuan*, Sheng-rong Guo, Jian-nan Xiang*

*Department of Chemistry, Lishui University, 323000 Lishui and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China, Email: guosr9609lsu.edu.cn, jnxianghnu.edu.cn

Y.-q. Yuan, S.-r. Guo, J.-n. Xiang, Synlett, 2013, 24, 443-448.

DOI: 10.1055/s-0032-1318188 (free Supporting Information)


Abstract

Cu(OAc)2-promoted TBHP oxidative coupling reaction of formamides with thiophenols gives S-aryl dialkyl thiocarbamates in high yield  under solvent-free conditions through direct C-H bond activation of formamides.


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Key Words

TBHP, Cu(OAc)2, thiolation, thiols, formamides


ID: J60-Y2013-0490