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Monophasic Catalytic System for the Selective Semireduction of Alkynes

Aaron M Whittaker and Gojko Lalic*

*Department of Chemistry, University of Washington, Seattle, Washington 98195, United States, Email:

A. M Whittaker, G. Lalic, Org. Lett., 2013, 15, 1112-1115.

DOI: 10.1021/ol4001679


Using small amounts of a copper catalyst, an efficient semireduction of alkynes can be accomplished with a wide range of substrates, including both internal and terminal alkynes without over-reduction. The new method has excellent chemoselectivity and tolerates nitro and aryl iodo groups. Finally, commercial availability of a catalyst precursor adds to the appeal of the new catalytic system.

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Key Words

semireduction of alkynes, PMHS

ID: J54-Y2013-0580