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Lewis Basic Selenium Catalyzed Chloroamidation of Olefins Using Nitriles as the Nucleophiles

Daniel Weiliang Tay, Ivan Tan Tsoi, Jun Cheng Er, Gulice Yiu Chung Leung* and Ying-Yeung Yeung*

*Department of Chemistry, National University of Singapore, Singapore 117543, and A*STAR−Institute of Chemical & Engineering Sciences, Singapore 138667, Email:,

D. W. Tay, I. T. Tsoi, J. C. Er, G. Y. C. Leung, Y.-Y. Yeung, Org. Lett., 2013, 15, 1310-1313.

DOI: 10.1021/ol400249x


The use of diphenyl selenide as a Lewis base catalyst enables a mild chloroamidation of a wide rand of olefinic substrates including starting materials with acid labile functional groups.

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Key Words

1,2-chloroamines, NCS

ID: J54-Y2013-0630