Iodobenzene Catalyzed C-H Amination of N-Substituted Amidines Using m-Chloroperbenzoic Acid
Santhosh Kumar Alla, Rapolu Kiran Kumar, Pradeep Sadhu and Tharmalingam Punniyamurthy*
*Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India, Email: tpunniiitg.ernet.in
S. K. Alla, R. K. Kumar, P. Sadhu, T. Punniyamurthy, Org. Lett., 2013, 15, 1334-1337.
see article for more reactions
The use of iodobenzene as a catalyst enables the synthesis of 1,2-disubstituted benzimidazoles by oxidative C-H amination of N″-aryl-N′-tosyl/N′-methylsulfonylamidines and N,N′-bis(aryl)amidines in the presence of mCPBA as terminal oxidant at room temperature. The reaction is general, and the target products can be obtained in good yields.
see article for more examples