Facile One-Pot Synthesis of 3,5-Disubstituted 1H-Pyrazoles from Propargylic Alcohols via Propargyl Hydrazides
Chada Raji Reddy*, Jonnalagadda Vijaykumar, René Grée
*Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India, Email: rajireddyiict.res.in
C. R. Reddy, J. Vijaykumar, R. Grée, Synthesis, 2013, 45, 830-836.
DOI: 10.1055/s-0032-1316856 (free Supporting Information)
A new and efficient metal-free, two-component, one-pot approach to a variety of 3,5-disubstituted 1H-pyrazoles from propargylic alcohols in good overall yields proceeds via an acid-catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated 5-endo-dig cyclization.
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pyrazoles, propargylic alcohols, one-pot reaction, acid catalysis, hydrazines