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Synthesis of Multisubstituted Imidazoles via Copper-Catalyzed [3 + 2] Cycloadditions

Dong Tang, Ping Wu, Xiang Liu, Yong-Xin Chen, Shuai-Bo Guo, Wen-Lin Chen, Jia-Gen Li and Bao-Hua Chen*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Gansu Lanzhou, 730000, P. R. China, Email: chbhlzu.edu.cn

D. Tang, P. Wu, X. Liu, Y.-X. Chen, S.-B. Guo, W.-L. Chen, J.-G. Li, B.-H. Chen, J. Org. Chem., 2013, 78, 2746-2750.

DOI: 10.1021/jo302555z (free Supporting Information)



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Abstract

A simple route via a copper-catalyzed [3 + 2] cycloaddition reaction provides multisubstituted imidazoles in good yields and high regioselectivity using oxygen as an oxidant without the addition of expensive catalysts.

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Key Words

imidazoles


ID: J42-Y2013-0740