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Unsupported Nanoporous Gold Catalyst for Highly Selective Hydrogenation of Quinolines

Mei Yan, Tienan Jin*, Qiang Chen, Hon Eong Ho, Takeshi Fujita, Lu-Yang Chen, Ming Bao, Ming-Wei Chen, Naoki Asao and Yoshinori Yamamoto

*WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japan, Email: tjinm.tohoku.ac.jp

M. Yan, T. Jin, Q. Chen, H. E. Ho, T. Fujita, L.-Y. Chen, M. Bao, M.-W. Chen, N. Asao, Y. Yamamoto, Org. Lett., 2013, 15, 1484-1487.

DOI: 10.1021/ol400229z (free Supporting Information)


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Abstract

The use of unsupported nanoporous gold (AuNPore) as a catalyst and organosilane with water as a hydrogen source enables a highly efficient and regioselective hydrogenation of quinoline derivatives to 1,2,3,4-tetrahydroquinolines. The AuNPore catalyst can be readily recovered and reused without any loss of catalytic activity.

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Key Words

Tetrahydroquinolines, Quinolines, Silanes


ID: J54-Y2013-0850