A Convenient One-Pot Synthesis of N-Substituted 2-Aminoazole Derivatives
Sirilata Yotphan*, Danupat Beukeaw, Vichai Reutrakul
*Center for Catalysis and Center of Excellence for Innovation
in Chemistry, Department of Chemistry, Faculty of Science, Mahidol University,
Bangkok 10400, Thailand, Email: sirilata.yot
mahidol.ac.th
S. Yotphan, D. Beukeaw, V. Reutrakul, Synthesis, 2013, 45, 936-942.
DOI: 10.1055/s-0032-1316868
see article for more reactions
Abstract
Simple azole substrates can be converted into N-substituted 2-aminoazole derivatives in the presence of nitrogen nucleophiles, lithium tert-butoxide as the base, and iodine to mediate carbon-nitrogen bond formation. This method proceeds at room temperature under an air atmosphere using a normal benchtop set-up, or can be performed conveniently using microwave irradiation.
see article for more examples
Key Words
N-substituted 2-aminoazoles, iodine, one-pot synthesis, benzoxazoles, carbon-nitrogen bond formation
ID: J66-Y2013-0880
