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Copper-Catalyzed Synthesis of Substituted Benzothiazoles via Condensation of 2-Aminobenzenethiols with Nitriles

Yadong Sun, Huanfeng Jiang*, Wanqing Wu, Wei Zeng and Xia Wu

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China, Email: jianghfscut.edu.cn

Y. Sun, H. Jiang, W. Wu, W. Zeng, X. Wu, Org. Lett., 2013, 15, 1598-1601.

DOI: 10.1021/ol400379z


Abstract

A copper-catalyzed condensation of 2-aminobenzenethiols with nitriles enables an efficient and convenient synthesis of 2-substituted benzothiazoles. The developed method is applicable to a wide range of nitriles containing different functional groups furnishing excellent yields of the corresponding products.

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Key Words

Benzothiazoles


ID: J54-Y2013-0910