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Synthesis of 2-Substituted Benzothiazoles from 1-Iodo-2-nitrobenzenes by a Copper-Catalyzed One-Pot Three-Component Reaction

Jidan Liu, Qingwen Gui, Zhiyong Yang, Ze Tan*, Ruqing Guo, Ji-Cheng Shi*

*Hunan University, Changsha 410082 and Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000, P. R. of China, Email: ztanzegmail.com, jchshi_mmc126.com

J. Liu, Q. Gui, Z. Yang, Z. Tan, R. Guo, J.-C. Shi, Synthesis, 2013, 45, 943-951.

DOI: 10.1055/s-0032-1318304


Abstract

A copper-catalyzed, one-pot, three-component reaction of 1-iodo-2-nitroarenes with sodium sulfide and an aldehyde gives 2-substituted 1,3-benzothiazoles in good yields.


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Key Words

catalysis, copper, multicomponent reactions, heterocycles, benzothiazoles, cyclizations, sulfur


ID: J66-Y2013-0920