Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow
Lukas M. Kreis, Simon Krautwald, Nicole Pfeiffer, Rainer E. Martin* and Erick M. Carreira*
*ETH-Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, and F.
Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland, Email:
carreira
org.chem.ethz.ch, rainer_e.martinroche.com
L. M. Kreis, S. Krautwald, N. Pfeiffer, R. E. Martin, E. M. Carreira, Org. Lett., 2013, 15, 1634-1637.
DOI: 10.1021/ol400410m
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Abstract
A cobalt-catalyzed photochemical synthesis of allylic trifluoromethanes from styrene derivatives using 2,2,2-trifluoroethyl iodide complements existing approaches, providing an alternative bond construction strategy to access these compounds. The process may be conducted in continuous mode in a photochemical flow reactor.
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Key Words
allylic trifluoromethanes, vinylation
ID: J54-Y2013-0940
