One-Pot Synthesis of Pentasubstituted Pyrroles from Propargylic Alcohols, Amines, and Dialkyl Acetylenedicarboxylates; Tandem Amination, Propargylation and Cycloisomerization Catalyzed by Molecular Iodine
Nisith Bhunia, Biswanath Das*
*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com
N. Bhunia, B. Das, Synthesis, 2013, 45, 1045-1050.
A simple, efficient, cost-effective, and metal-free multicomponent one-pot synthesis with amines, dialkyl acetylenedicarboxylates, and propargylic alcohols afforded fully substituted pyrroles in high yields in three hours using iodine as a catalyst.
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