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One-Pot Synthesis of Pentasubstituted Pyrroles from Propargylic Alcohols, Amines, and Dialkyl Acetylenedicarboxylates; Tandem Amination, Propargylation and Cycloisomerization Catalyzed by Molecular Iodine

Nisith Bhunia, Biswanath Das*

*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

N. Bhunia, B. Das, Synthesis, 2013, 45, 1045-1050.

DOI: 10.1055/s-0032-1318485


A simple, efficient, cost-effective, and metal-free multicomponent one-pot synthesis with amines, dialkyl acetylenedicarboxylates, and propargylic alcohols afforded fully substituted pyrroles in high yields in three hours using iodine as a catalyst.

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Key Words

pyrroles, tandem reactions, multicomponent reactions, iodine, metal-free synthesis

ID: J66-Y2013-1000