C-Acylation of Cyclopropanols: Preparation of Functionalized 1,4-Diketones
Bibhuti Bhusan Parida, Pragna Pratic Das, Mathilde Niocel and Jin Kun Cha*
*Department of Chemistry, Wayne State University, 5101 Cass
Avenue, Detroit, Michigan 48202, United States, Email: jcha
chem.wayne.edu
B. B. Parida, P. P. Das, M. Niocel, J. K. Cha, Org. Lett., 2013, 15, 1752-1783.
DOI: 10.1021/ol400666x
Abstract
A palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides enables a convenient method for preparing attractively functionalized 1,4-diketones. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.
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Key Words
ID: J54-Y2013-1030
