Organocatalytic Knoevenagel Condensations by Means of Carbamic Acid Ammonium Salts
Nobuyuki Mase* and Takuya Horibe
*Department of Molecular Science, Faculty of Engineering,
Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Japan, Email: tnmase
ipc.shizuoka.ac.jp
N. Mase, T. Horibe, Org. Lett., 2013, 15, 1854-1857.
DOI: 10.1021/ol400462d
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Abstract
In the presence of a carbamic acid ammonium salt as an organocatalyst, the Knoevenagel condensation between an active methylene compound and an aromatic aldehyde gave the desired Knoevenagel products in good yields at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.
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Key Words
Knoevenagel Condensation, Green Chemistry
ID: J54-Y2013
