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Enantioselective Ketone Hydroacylation Using Noyori's Transfer Hydrogenation Catalyst

Stephen K. Murphy and Vy M. Dong*

*Department of Chemistry, University of California, Irvine, California 92697-2025, United States, Email:

S. K. Murphy, V. M. Dong, J. Am. Chem. Soc., 2013, 135, 5553-5556.

DOI: 10.1021/ja4021974

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An efficient, chemo- and enantioselective ketone hydroacylation enables the direct preparation of lactones from keto alcohols in the presence of Noyori's asymmetric transfer hydrogenation catalyst. The alcohol is oxidized in situ to an aldehyde, obviating the need to prepare sensitive keto aldehyde substrates.

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Key Words


ID: J48-Y2013