Enantioselective Ketone Hydroacylation Using Noyori's Transfer Hydrogenation Catalyst
Stephen K. Murphy and Vy M. Dong*
*Department of Chemistry, University of California, Irvine,
California 92697-2025, United States, Email: dongv
uci.edu
S. K. Murphy, V. M. Dong, J. Am. Chem. Soc., 2013, 135, 5553-5556.
DOI: 10.1021/ja4021974
see article for more reactions
Abstract
An efficient, chemo- and enantioselective ketone hydroacylation enables the direct preparation of lactones from keto alcohols in the presence of Noyori's asymmetric transfer hydrogenation catalyst. The alcohol is oxidized in situ to an aldehyde, obviating the need to prepare sensitive keto aldehyde substrates.
see article for more examples
Key Words
ID: J48-Y2013
