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Multicomponent Multicatalyst Reactions (MC)2R: One-Pot Synthesis of 3,4-Dihydroquinolinones

Lei Zhang, Lorenzo Sonaglia, Jason Stacey and Mark Lautens*

*Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada, Email:

L. Zhang, L. Sonaglia, J. Stacey, M. Lautens, Org. Lett., 2013, 15, 2128-2131.

DOI: 10.1021/ol4006008


A Rh/Pd/Cu catalyst system led to an efficient one-pot synthesis of dihydroquinolinones without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.

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Key Words

3,4-Dihydroquinolinones, Arylation

ID: J54-Y2013