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P-Arylation: Arynes to Aryl-Phosphonates, -Phosphinates, and -Phosphine Oxides

Ranjeet A. Dhokale and Santosh B. Mhaske*

*Division of Organic Chemistry, National Chemical Laboratory (CSIR-NCL), Pune 411008, India, Email:

R. A. Dhokale, S. B. Mhaske, Org. Lett., 2013, 15, 2218-2221.

DOI: 10.1021/ol400780f (free Supporting Information)

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An efficient use of arynes for C-P bond construction enables a mild process for the synthesis of aryl-phosphonates, -phosphinates, and -phosphine oxides. The reaction circumvents the relatively harsh reaction conditions using transition-metal-catalyzed P-arylation (Arbuzov/Hirao reaction).

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Key Words

phosphonates, phosphinates, phosphine oxides

ID: J54-Y2013