Palladium-Catalyzed Formal Hydroacylation of Allenes Employing Acid Chlorides and Hydrosilanes
Tetsuaki Fujihara, Kenta Tatsumi, Jun Terao and Yasushi Tsuji*
*Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan, Email: ytsujiscl.kyoto-u.ac.jp
T. Fujihara, K. Tatsumi, J. Terao, Y. Tsuji, Org. Lett., 2013, 15, 2286-2289.
A catalyzed formal hydroacylation of allenes with acid chlorides proceeds with commercially available Pd(OAc)2 as catalyst and HSi(iPr)3 as reducing reagent to yield the corresponding α,β-unsaturated ketones regio- and stereoselectively.
see article for more examples