Palladium-Catalyzed Addition of Potassium Aryltrifluoroborates to Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones, Diketone Compounds, and 2-Arylbenzo[b]furans
Xingyong Wang, Miaochang Liu, Long Xu, Qingzong Wang, Jiuxi Chen*, Jinchang Ding and Huayue Wu*
*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email: jiuxichenwzu.edu.cn, huayuewuwzu.edu.cn
X. Wang, M. Liu, L. Xu, Q. Wang, J. Chen, J. Ding, H. Wu, J. Org. Chem., 2013, 78, 5273-5281.
DOI: 10.1021/jo400433m
Abstract
A palladium-catalyzed addition of potassium aryltrifluoroborates to aliphatic nitriles leads to a wide range of alkyl aryl ketones with good yields. The scope of the developed approach is successfully explored toward the one-step synthesis of 2-arylbenzo[b]furans via sequential addition and intramolecular annulation reactions. The methodology accepted a wide range of substrates and is applicable to library synthesis.
see article for more examples
X. Wang, X. Wang, M. Liu, J. Ding, J. Chen, H. Wu, Synthesis, 2013, 45, 2241-2244.
Key Words
ID: J42-Y2013