Amide Bond Formation through Iron-Catalyzed Oxidative Amidation of Tertiary Amines with Anhydrides
Yuanming Li, Lina Ma, Fan Jia and Zhiping Li*
*Department of Chemistry, Renmin University of China, Beijing 100872, China, Email: zhipingliruc.edu.cn
Y. Li, L. Ma, F. Jia, Z. Li, J. Org. Chem., 2013, 78, 5638-5646.
DOI: 10.1021/jo400804p (free Supporting Information)
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A general and efficient method enables the synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl2 as catalyst and tert-butyl hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated α-amino peroxide of tertiary amine and iminium ion act as key intermediates.
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