Catalytic Asymmetric Oxidation of N-Sulfonyl Imines with Hydrogen Peroxide-Trichloroacetonitrile System
Daisuke Uraguchi, Ryosuke Tsutsumi and Takashi Ooi*
*Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya
University, Nagoya 464-8602, Japan, Email:
tooi
apchem.nagoya-u.ac.jp
D. Uraguchi, R. Tsutsumi, T. Ooi, J. Am. Chem. Soc., 2013, 135, 8161-8164.
DOI: 10.1021/ja403491j
Abstract
An efficient and highly enantioselective Payne-type oxidation of N-sulfonyl imines exhibits broad substrate generality and unique chemoselectivity based on the combined use of hydrogen peroxide and trichloroacetonitrile under the catalysis of P-spiro chiral triaminoiminophosphorane.
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Key Words
N-Heterocycles, O-Heterocycles, Hydrogen Peroxide, Organocatalysis
ID: J48-Y2013
