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Copper-Promoted Sandmeyer Trifluoromethylation Reaction

Jian-Jun Dai, Chi Fang, Bin Xiao, Jun Yi, Jun Xu, Zhao-Jing Liu, Xi Lu, Lei Liu and Yao Fu*

*Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, Email:

J.-J. Dai, C. Fang, B. Xiao, J. Yi, J. Xu, Z.-J. Liu, X. Lu, L. Liu, Y. Fu, J. Am. Chem. Soc., 2013, 135, 8436-8439.

DOI: 10.1021/ja404217t


A mild, copper-promoted Sandmeyer trifluoromethylation of aromatic amines proceeds smoothly and exhibits good tolerance of many synthetically relevant functional groups. The reaction provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes.

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Key Words

Sandmeyer Reaction, Trifluoromethylation

ID: J48-Y2013