Copper-Promoted Sandmeyer Trifluoromethylation Reaction
Jian-Jun Dai, Chi Fang, Bin Xiao, Jun Yi, Jun Xu, Zhao-Jing Liu, Xi Lu, Lei Liu and Yao Fu*
*Department of Chemistry, University of Science and
Technology of China, Hefei 230026, China, Email: fuyao
ustc.edu.cn
J.-J. Dai, C. Fang, B. Xiao, J. Yi, J. Xu, Z.-J. Liu, X. Lu, L. Liu, Y. Fu, J. Am. Chem. Soc., 2013, 135, 8436-8439.
DOI: 10.1021/ja404217t
Abstract
A mild, copper-promoted Sandmeyer trifluoromethylation of aromatic amines proceeds smoothly and exhibits good tolerance of many synthetically relevant functional groups. The reaction provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes.
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Key Words
Sandmeyer Reaction, Trifluoromethylation
ID: J48-Y2013
