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A Mild Chemoselective Ru-Catalyzed Reduction of Alkynes, Ketones, and Nitro Compounds

Tobias Schabel, Christian Belger and Bernd Plietker*

*Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, DE-70569 Stuttgart, Germany, Email: bernd.plietkeroc.uni-stuttgart.de

T. Schabel, C. Belger, B. Plietker, Org. Lett., 2013, 15, 2858-2861.

DOI: 10.1021/ol401185t (free Supporting Information)


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Abstract

(Ph3P)3RuCl2 is an inexpensive catalyst, that enables a chemoselective reduction of alkyne, ketones, or nitro groups in the presence of Zn/water as a stoichiometric reductant. Depending on the nature of the additive and the temperature, chemoselective reduction of a nitro group in the presence of a ketone or an alkyne was possible.

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Key Words

Reduction of Alkynes, Reduction of Nitro Compounds, Zinc


ID: J54-Y2013