Synthesis of Indolines via Pd(II)-Catalyzed Amination of C-H Bonds Using PhI(OAc)2 as the Bystanding Oxidant
Tian-Sheng Mei, Dasheng Leow, Han Xiao, Brian N. Laforteza and Jin-Quan Yu*
*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Email: yu200Scripps.edu
T.-S. Mei, D. Leow, H. Xiao, B. N. Laforteza, J.-Q. Yu, Org. Lett., 2013, 15, 3058-3061.
DOI: 10.1021/ol401246u
Abstract
A Pd(II)-catalyzed intramolecular C-H amination of 2-pyridinesulfonyl-protected phenethylamine derivatives using PhI(OAc)2 as a bystanding oxidant provides access to various substituted indoline derivatives in good yields. The use of the 2-pyridinesulfonyl protecting group enables a facile deprotection following C-H functionalization.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
ID: J54-Y2013