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TEMPO-Mediated Aliphatic C-H Oxidation with Oximes and Hydrazones

Xu Zhu, Yi-Feng Wang, Wei Ren, Feng-Lian Zhang and Shunsuke Chiba*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore, Email: shunsukentu.edu.sg

X. Zu, Y.-F. Wang, W. Ren, F.-L. Zhang, S. Chiba, Org. Lett., 2013, 15, 3214-3214.

DOI: 10.1021/ol4014969 (free Supporting Information)


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Abstract

A method for aliphatic C-H bond oxidation of oximes and hydrazones mediated by 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) enables the concise assembly of substituted isoxazole and pyrazole skeletons.

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Key Words

2-isoxazolines, TEMPO


ID: J54-Y2013