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Nickel-Catalyzed Borylation of Halides and Pseudohalides with Tetrahydroxydiboron [B2(OH)4]

Gary A. Molander*, Livia N. Cavalcanti and Carolina García-García

*Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States, Email:

G. A. Molander, L. N. Cavalcanti, C. García-García, J. Org. Chem., 2013, 78, 6427-6439.

DOI: 10.1021/jo401104y (free Supporting Information)


A nickel-catalyzed Miyaura borylation of aryl and heteroaryl halides and pseudohalides using tetrahydroxydiboron (BBA) proved to be widely functional group tolerant and applicable to the synthesis of a broad range of aryltrifluoroborates at room temperature.

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Palladium-Catalyzed, Direct Boronic Acid Synthesis from Aryl Chlorides: A Simplified Route to Diverse Boronate Ester Derivatives

G. A. Molander, S. L. J. Trice, S. D. Dreher, J. Am. Chem. Soc., 2010, 132, 17701-17703.

Key Words

Miyaura Borylation, Aryltrifluoroborates

ID: J42-Y2013