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Copper-Catalyzed Formamidation of Arylboronic Acids: Direct Access to Formanilides

Vishnu P. Srivastava, Deepak K. Yadav, Arvind K. Yadav, Geeta Watal, Lal Dhar S. Yadav*

*Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India, Email:

V. P. Srivastava, D. K. Yadav, A. K. Yadav, G. Watal, L. D. S. Yadav, Synlett, 2013, 24, 1423-1427.

DOI: 10.1055/s-0033-1338453


A mild and highly efficient direct synthesis of formanilides from structurally varied arylboronic acids involves a copper-catalyzed Chan-Lam coupling reaction between arylboronic acids and formamide in the presence of a base at room temperature. The strategy offers a valid and practical alternative to existing transformations especially as arylboronic acids are easily accessible, stable, and diversified substrates.

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Key Words

formamides, formanilides, arylboronic acids, C-N cross-coupling, N-arylation, Chan-Lam Coupling

ID: J60-Y2013