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Metal-Free Decarboxylative Three-Component Coupling Reaction for the Synthesis of Propargylamines

Kyungho Park, Yumi Heo and Sunwoo Lee*

*Department of Chemistry, Chonnam National University, Gwangju, 500-757, Republic of Korea, Email: sunwoochonnam.ac.kr

K. Park, Y. Heo, S. Lee, Org. Lett., 2013, 15, 3322-3325.

DOI: 10.1021/ol401358t


Abstract

A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in MeCN at 65 °C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.

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Key Words

Alkynylation, Amination, Multicomponent Reactions


ID: J54-Y2013