Pd-Catalyzed Cross-Coupling of Potassium Alkenyltrifluoroborates with 2-Chloroacetates and 2-Chloroacetamides
Gary A. Molander*, Thiago Barcellos and Kaitlin M. Traister
*Roy and Diana Vagelos Laboratories, Department of Chemistry,
University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania
19104-6323, United States., Email: gmolandr
sas.upenn.edu
G. A. Molander, T. Barcellos, K. M. Traister, Org. Lett., 2013, 15, 3342-3345.
DOI: 10.1021/ol401377q
Abstract
2-Chloroacetates as well as secondary and tertiary 2-chloroacetamides were successfully employed as electrophiles in the Suzuki-Miyaura cross-coupling reaction with potassium (E)- and (Z)-alkenyltrifluoroborates, affording the corresponding (E)- and (Z)-β,γ-unsaturated esters and amides in high yield.
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Key Words
ID: J54-Y2013
