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Direct Amination of Phenols under Metal-Free Conditions

Jianzhong Yu, Yongtao Wang, Peizhi Zhang, Jun Wu*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China, Email:

J. Yu, Y. Wang, P. Zhang, J. Wu, Synlett, 2013, 24, 1448-1454.

DOI: 10.1055/s-0033-1338703


A metal-free synthesis of arylamines via the direct amination of phenols using easily accessible aminating reagents provides a versatile route to a broad range of arylamines with various functionalities in good yield. By using a two-step route of amination and oxidative coupling reaction, three naturally occurring carbazole alkaloids are synthesized from commercially available phenols: murrayafoline A, mukonine, and clausenine.

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Key Words

amination, phenols, metal-free, arylamines, anilines, carbazoles

ID: J60-Y2013