Multicomponent Synthesis of 1-Aryl 1,2,4-Triazoles
Annie Tam, Ian S. Armstrong and Thomas E. La Cruz*
*Chemical Development, Bristol-Myers Squibb, 1 Squibb Drive,
New Brunswick, New Jersey 08903, United States, Email: thomas.lacruz
bms.com
A. Tam, I. S. Armstrong, T. E. La Cruz, Org. Lett., 2013, 15, 3585-3589.
DOI: 10.1021/ol401428x
Abstract
A multicomponent process enables the synthesis of 1-aryl 1,2,4-triazoles directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates.
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Key Words
1,2,4-triazoles, multicomponent reactions
ID: J54-Y2013
