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Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex

Weiwei Fang, Qinyue Deng, Mizhi Xu and Tao Tu*

*Department of Chemistry, Fudan University, 220 Handan Road, 200433, Shanghai, China, Email: taotufudan.edu.cn

W. Fang, Q. Deng, M. Xu, T. Tu, Org. Lett., 2013, 15, 3678-3681.

DOI: 10.1021/ol401550h (free Supporting Information)


Abstract

A robust allylic palladium-NHC complex exhibited extremely high catalytic activity toward aminocarbonylation of various aryl iodides under atmospheric carbon monoxide pressure. A broad range of secondary and primary amines were tolerated. A gram scale synthesis of the anticancer drug tamibarotene further highlightes the practical applicability of the protocol.

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Key Words

aminocarbonylation


ID: J54-Y2013