General and Regioselective Synthesis of Pyrroles via Ruthenium-Catalyzed Multicomponent Reactions
Min Zhang, Xianjie Fang, Helfried Neumann and Matthias Beller*
*Leibniz-Institut für Katalyse an der Universität Rostock
e.V., Albert-Einstein-Strasse 29a, 18059 Rostock, Germany, Email:
matthias.beller
catalysis.de
M. Zahng, X. Fang, H. Neumann, M. Beller, J. Am. Chem. Soc., 2013, 135, 11384-11388.
DOI: 10.1021/ja406666r
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Abstract
In ruthenium-catalyzed three-component reactions, ketones, amines, and vicinal diols are converted into various substituted pyrroles in good isolated yields. Additionally, α-functionalized ketones gave synthetically interesting amido-, alkoxy-, aryloxy-, and phosphate-substituted pyrroles in a straightforward manner. The synthetic protocol proceeds with high atom-efficiency and shows a broad substrate scope and functional group tolerance.
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Key Words
pyrroles, multicomponent reactions
ID: J48-Y2013
