Synthesis of 3-Acyl-2-arylindole via Palladium-catalyzed Isocyanide Insertion and Oxypalladation of Alkyne
Takeshi Nanjo, Sho Yamamoto, Chihiro Tsukano and Yoshiji Takemoto*
*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan, Email: takemotopharm.kyoto-u.ac.jp
T. Nanjo, S. Yamamoto, C. Tsukano, Y. Takemoto, Org. Lett., 2013, 15, 3754-3757.
DOI: 10.1021/ol4016699 (free Supporting Information)
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Palladium-catalyzed isocyanide insertion and oxypalladation of an alkyne enables the synthesis of 3-acyl-2-arylindole derivatives. In addition, domino cyclizations for the synthesis of several tetracyclic indole derivatives were also achieved.
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