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Mild Negishi Cross-Coupling Reactions Catalyzed by Acenaphthoimidazolylidene Palladium Complexes at Low Catalyst Loadings

Zelong Liu, Ningning Dong, Mizhi Xu, Zheming Sun and Tao Tu*

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China, Email:

Z. Liu, N. Dong, M. Xu, Z. Sun, T. Tu, J. Org. Chem., 2013, 78, 7436-7444.

DOI: 10.1021/jo400803s


Robust acenaphthoimidazol-ylidene palladium complexes with varying bulky substituted groups exhibited extremely high catalytic activity toward Negishi cross-coupling of alkylzinc reagents with a wide range of (hetero)aryl halides under mild reaction conditions within short reaction times. Besides a great number of bromoarenes, various less expensive and inactive (hetero)aryl chlorides were coupled successfully with alkyl- and arylzinc reagents.

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Key Words

Negishi Coupling, Alkylation

ID: J42-Y2013