Catalytic Asymmetric Three-Component 1,3-Dipolar Cycloaddition of Aldehydes, Hydrazides, and Alkynes
Takuya Hashimoto, Yuka Takiguchi and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto
University, Sakyo, Kyoto 606-8502, Japan, Email: maruoka
kuchem.kyoto-u.ac.jp
T. Hashimoto, Y. Takiguchi, K. Maruoka, J. Am. Chem. Soc., 2013, 135, 11473-11476.
DOI: 10.1021/ja405444c
Abstract
A catalytic asymmetric 1,3-dipolar cycloaddition of terminal alkynes with acyclic azomethine imines generated in situ from the corresponding aldehydes and hydrazides was realized using Cu(I)/pybox and axially chiral dicarboxylic acid cocatalysts.
see article for more examples
Key Words
3-pyrazolines, multicomponent reactions
ID: J48-Y2013
