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Ruthenium-Catalyzed Redox-Neutral and Single-Step Amide Synthesis from Alcohol and Nitrile with Complete Atom Economy

Byungjoon Kang, Zhenqian Fu and Soon Hyeok Hong*

*Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea, Email:

B. Kang, Z. Fu, S. H. Hong, J. Am. Chem. Soc., 2013, 135, 11704-11707.

DOI: 10.1021/ja404695t


In a completely atom-economical and redox-neutral catalytic amide synthesis from an alcohol and a nitrile, the amide C-N bond is efficiently formed between the nitrogen atom of nitrile and the α-carbon of alcohol, with the help of an N-heterocyclic carbene-based ruthenium catalyst, without a single byproduct.

see article for more examples

Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes

S. Muthaiah, S. C. Ghosh, J.-E. Jee, C. Chen, J. Zahng, S. H. Hong, J. Org. Chem., 2010, 75, 3002-3006.

Key Words


ID: J48-Y2013