Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst
Chi Wai Cheung and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of
Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United
States, Email: sbuchwal
mit.edu
C. W. Cheung, S. L. Buchwald, Org. Lett., 2013, 15, 3966-3969.
DOI: 10.1021/ol401796v
Abstract
A general Pd-catalyzed coupling of methanol with (hetero)aryl halides proceeds under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.
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Key Words
ID: J54-Y2013
