Enantioselective α-Alkenylation of Aldehydes with Boronic Acids via the Synergistic Combination of Copper(II) and Amine Catalysis
Jason M. Stevens and David W. C. MacMillan*
*Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States, Email: dmacmillprinceton.edu
J. M. Stevens. D. W. C. MacMillan, J. Am. Chem. Soc., 2013, 135, 11756-11757.
DOI: 10.1021/ja406356c
Abstract
A synergistic combination of copper and chiral amine catalysis enables an enantioselective α-alkenylation of aldehydes using boronic acids. The merger of two highly utilized and robust catalytic systems has allowed for the development of a mild and operationally trivial protocol for the direct formation of α-formyl olefins employing common building blocks for organic synthesis.
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E. Skucas, D. W. C. MacMillan, J. Am. Chem. Soc., 2012, 134, 9090-9093.
Key Words
ID: J48-Y2013