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Palladium-Catalyzed Benzylation of Carboxylic Acids with Toluene via Benzylic C-H Activation

Hongqiang Liu, Guangfa Shi, Shulei Pan, Yuyu Jiang and Yanghui Zhang*

*Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China, Email:

H. Liu, G. Shi, S. Pan, Y. Jiang, Y. Zhang, Org. Lett., 2013, 15, 4098-4101.

DOI: 10.1021/ol401687f (free Supporting Information)


A direct benzylation of carboxylic acids with toluene via palladium-catalyzed C-H acyloxylation under 1 atm of oxygen demonstrates good functional group tolerance and high yields. The method provides a facile, atom-economic, and efficient synthesis of benzyl esters.

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Key Words

benzyl esters

ID: J54-Y2013