Palladium-Catalyzed Benzylation of Carboxylic Acids with Toluene via Benzylic C-H Activation
Hongqiang Liu, Guangfa Shi, Shulei Pan, Yuyu Jiang and Yanghui Zhang*
*Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China, Email: zhangyanghuitongji.edu.cn
H. Liu, G. Shi, S. Pan, Y. Jiang, Y. Zhang, Org. Lett., 2013, 15, 4098-4101.
DOI: 10.1021/ol401687f (free Supporting Information)
A direct benzylation of carboxylic acids with toluene via palladium-catalyzed C-H acyloxylation under 1 atm of oxygen demonstrates good functional group tolerance and high yields. The method provides a facile, atom-economic, and efficient synthesis of benzyl esters.
see article for more examples