Palladium-Catalyzed Direct Intermolecular α-Arylation of Amides with Aryl Chlorides
Bing Zheng, Tiezheng Jia and Patrick J. Walsh*
*Department of Chemistry, University of Pennsylvania, 231
South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States, Email:
pwalsh
sas.upenn.edu
B. Zheng, T. Jia, P. Walsh, Org. Lett., 2013, 15, 4150-4153.
DOI: 10.1021/ol4019002
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Abstract
An efficient Pd-catalyzed direct intermolecular α-arylation of acetamide derivatives with aryl chlorides offers chemoselectivities up to 10:1 in mono- and diarylation by careful selection of bases, solvents, and stoichiometry. Bis-arylated amides can be prepared in up to 95% yield.
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Key Words
ID: J54-Y2013
