Gold-Mediated Synthesis and Functionalization of Chiral Halopyridones
Khanh Hung Nguyen, Sophie Tomasi, Myriam Le Roch, Loïc Toupet, Jacques Renault, Philippe Uriac and Nicolas Gouault*
*Equipe PNSCM, UMR 6226, Université de Rennes 1, 2 avenue du
Pr. Léon Bernard 35043 Rennes Cedex, France, Email: nicolas.gouault
univ-rennes1.fr
K. H. Nguyen, S. Tomasi, M. Le Roch, L. Toupet, J. Renault, P. Uriac, N. Gouault, J. Org. Chem., 2013, 78, 7809-7815.
DOI: 10.1021/jo400827b
see article for more reactions
Abstract
A gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process enables a rapid and efficient one-step halopyridone synthesis.
see article for more examples
Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines
N. Gouault, M. Le Roch, A. Cheignon, P. Uriac, M. David, Org. Lett., 2011, 13, 4371-4373.
Key Words
2,3-dihydro-4-pyridones, NBS, NIS
ID: J42-Y2013
