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Palladium-Catalyzed Reaction of Arylboronic Acids with Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans

Xingyong Wang, Xiaodong Wang, Miaochang Liu*, Jinchang Ding, Jiuxi Chen*, Huayue Wu

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:,

X. Wang, X. Wang, M. Liu, J. Ding, J. Chen, H. Wu, Synthesis, 2013, 45, 2241-2244.

DOI: 10.1055/s-0033-1338909 (free Supporting Information)


An efficient palladium-catalyzed addition of arylboronic acids to aliphatic nitriles provides a broad range of alkyl aryl ketones in good yields. It is noteworthy that sequential addition and intramolecular annulation reactions of 2-(2-hydroxyphenyl)acetonitriles with arylboronic acids smoothly afford 2-arylbenzofurans in good yields under the standard conditions.

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Palladium-Catalyzed Addition of Potassium Aryltrifluoroborates to Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones, Diketone Compounds, and 2-Arylbenzo[b]furans

X. Wang, M. Liu, L. Xu, Q. Wang, J. Chen, J. Ding, H. Wu, J. Org. Chem., 2013, 78, 5273-5281.

Key Words

palladium, aliphatic nitriles, arylboronic acids, alkyl aryl ketones, 2-arylbenzofurans

ID: J66-Y2013