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Direct Transformation of Amides into α-Amino Phosphonates via a Reductive Phosphination Process

Yuzhen Gao, Zhongbin Huang, Rongqiang Zhuang, Jian Xu, Pengbo Zhang, Guo Tang* and Yufen Zhao

*Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China, Email:

Y. Gao, Z. Huang, R. Zhuang, J. Xu, P. Zhang, G. Tang, Y. Zhao, Org. Lett., 2013, 15, 4214-4217.

DOI: 10.1021/ol4019419


A general method for the reductive phosphination of amides in one pot provides α-amino phosphonates in very good yields. The reaction covers a broad scope of substrates such as secondary and tertiary amides.

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Key Words

α-Amino Phosphonates, Schwartz Reagent

ID: J54-Y2013