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Highly Efficient Chemoselective Synthesis of Polysubstituted Pyrroles via Isocyanide-Based Multicomponent Domino Reaction

Xiang Wang, Xiao-Ping Xu, Shun-Yi Wang*, Weiqun Zhou and Shun-Jun Ji*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China, Email:,

X. Wang, X.-P. Xu, S.-Y. Wang, W. Zhou, S.-J. Ji, Org. Lett., 2013, 15, 4246-4249.

DOI: 10.1021/ol401976w (free Supporting Information)


A multicomponent domino reaction of readily available isocyanides, primary or secondary amines, and gem-diactivated olefins enables a chemoselective, catalyst-free synthesis of structurally diverse, polysubstituted pyrroles in good yields under mild conditions.

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Key Words

Pyrroles, Multicomponent Reactions

ID: J54-Y2013