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An Efficient and Convenient Procedure for the One-Pot Synthesis of α-Aminophosphonates from Aryl Azides under Solvent-Free Conditions

Ya-Qin Yu*

*Key Laboratory for Water Environment and Resources, Tianjin Normal University, Tianjin 300387, P. R. of China, Email:

Y.-Q. Yu, Synthesis, 2013, 45, 2545-2550.

DOI: 10.1055/s-0033-1339377 (free Supporting Information)

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A simple multicomponent reaction of aldehydes, diethyl phosphite, and azides gives α-aminophosphonates in the presence of iodine and iron under solvent-free conditions. The reactions were completed at room temperature within 5 minutes to 12 hours and afforded the corresponding products in good yields.

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Key Words

α-aminophosphonates, azides, multicomponent reactions, solvent-free conditions, iodine

ID: J66-Y2013