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Aerobic Synthesis of Substituted Quinoline from Aldehyde and Aniline: Copper-Catalyzed Intermolecular C-H Active and C-C Formative Cyclization

Rulong Yan*, Xingxing Liu, Congming Pan, Xiaoqiang Zhou, Xiaoni Li, Xing Kang and Guosheng Huang*

*State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, China, Email:,

R. Yan, X. Liu, C. Pan, X. Zhou, X. Li, X. Kang, G. Huang, Org. Lett., 2013, 15, 4876-4879.

DOI: 10.1021/ol402312h


A simple and efficient method enables a direct synthesis of substituted quinolines from anilines and aldehydes through C-H functionalization, C-C/C-N bond formation, and C-C bond cleavage in the presence of air as an oxidant.

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Key Words

quinolines, oxygen

ID: J54-Y2013